解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90071-x
更新日期:1994-04-29 00:00:00
abstract::We have investigated whether ablation of normal rat liver by ultrasound can be enhanced after administration of a photosensitizing agent (Photofrin II). After laparotomy and administration of Photofrin II (30 mg/kg), ultrasound (210 kHz, 1.3 W/cm2) was directed directly to the surface of the liver for a total duration...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90048-5
更新日期:1994-04-01 00:00:00
abstract::Previously, we have shown that dietary retinoic acid (RA) at pharmacological doses (30 micrograms/g of diet) inhibited the malignant conversion of skin papillomas to carcinomas induced by a two-stage carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA)...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90032-9
更新日期:1994-04-01 00:00:00
abstract::An in vivo micronucleus assay using bone marrow cells of Syrian albino male mice for identifying the possibility of induction of adaptive response to various doses of radiation following treatment with chemotherapeutics is described. Single doses of bleomycin sulfate (BLM-S) at 300 micrograms/kg and actinomycin-D (ACT...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90043-4
更新日期:1994-04-01 00:00:00
abstract::Cervical cytology specimens prepared as monolayers were analyzed with a combination of high-resolution single-cell image analysis and lower-resolution contextual image analysis. For the latter, quantitative features of cluster architecture, object distribution and background were used to mimic the pathologists global ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90096-5
更新日期:1994-03-15 00:00:00
abstract::Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90090-6
更新日期:1994-03-15 00:00:00
abstract::Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90344-1
更新日期:1994-02-28 00:00:00
abstract::N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively. The enhancem...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90387-5
更新日期:1994-01-30 00:00:00
abstract::We investigated effects of sex steroids and analogs (estradiol, DES, norgestrel, progesterone, medroxyprogesterone, and testosterone) on the proliferation and survival of 10 human leukemia/lymphoma cell lines (HL-60, K562, U937, CEM, KG-1, Jurkat, U266, H929, PA and SUNHL). Micromolar concentrations of sex steroids ex...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90381-6
更新日期:1994-01-30 00:00:00
abstract::The addition of recombinant human interleukin-6 (rIL-6) to either soleus or extensor digitorum longus (EDL) muscle preparations did not affect the rate of protein breakdown as measured by the rate of tyrosine released to the medium. In addition, the presence of the cytokine did not influence either the rate of protein...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90126-0
更新日期:1994-01-15 00:00:00
abstract::In this report we demonstrated that [3H]suramin enters polarized human colon adenocarcinoma cells when added to the apical side of the monolayer. Using light microscopic quantitative autoradiography, we showed that suramin was accumulated in the apical cytoplasm and in the nucleus. In contrast, a weak labeling was not...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90057-g
更新日期:1993-12-20 00:00:00
abstract::The mouse monoclonal anti-BAL antibody induced apoptosis in a pre-B acute lymphocytic leukemia cell line within 2 days of incubation, after being crosslinked by a secondary antibody. The antibody specifically recognized a 37 kDa membrane protein that was expressed on a wide spectrum of normal and malignant cells, but ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90194-e
更新日期:1993-12-10 00:00:00
abstract::Chemically-induced mutagenesis and carcinogenesis is modulated by various plant products, some of which are present in the human diet. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen in tobacco and tobacco smoke, is activated by microsomal enzymes. In this study, we investigated the effects o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90206-o
更新日期:1993-11-30 00:00:00
abstract::The significance of altered expression of MN blood group antigens was examined by studies on the expressions of Thomsen-Friedenreich antigen (T antigen) and Tn antigen in primary and metastatic lesions of 29 human uterine cervical cancers. These antigens were measured by the avidin-biotin-peroxidase (ABC) method with ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90239-6
更新日期:1993-11-01 00:00:00
abstract::cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90049-f
更新日期:1993-10-15 00:00:00
abstract::N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90041-7
更新日期:1993-10-15 00:00:00
abstract::It is known that the ingestion of cooked meat which contains carcinogenic heterocyclic amines causes increase in urinary mutagenicity in humans. Using 6 healthy non-smokers, we examined the effect of 3-week oral administration of Lactobacillus casei (bacilli commonly present in yoghurt), on the urinary mutagenicity de...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90261-7
更新日期:1993-09-30 00:00:00
abstract::HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90189-g
更新日期:1993-09-15 00:00:00
abstract::A series of experiments was carried out to assess cytotoxic and cytogenetic effects in bone marrow polychromatic erythrocytes (PCE) and pulmonary alveolar macrophages (PAM) resulting from individual or combined exposure of male BD6 rats to ethanol, cigarette smoke and Aroclor 1254. Addition of 5% ethanol to drinking w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90127-u
更新日期:1993-08-31 00:00:00
abstract::The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the ef...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90006-u
更新日期:1993-08-16 00:00:00
abstract::Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90015-2
更新日期:1993-08-16 00:00:00
abstract::Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90112-m
更新日期:1993-07-30 00:00:00
abstract::In order to discover the role in the promotion process of 5-lipoxygenase (5-LO), a key enzyme in the arachidonate cascade, the antipromoting effects of the 5-LO inhibiting 3-nitro-2,4,6-trihydroxybenzamide (NTB) derivatives were studied in a two-stage transformation assay system using BALB 3T3 cells. All compounds inh...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90097-s
更新日期:1993-07-30 00:00:00
abstract::The retinoblastoma (Rb) gene is associated with the pathogenesis of several types of human cancer, including retinoblastoma, osteosarcoma, soft tissue sarcomas, and lung, breast and bladder carcinomas. Loss of heterozygosity is a common mode in allelic inactivation of Rb and other tumor-suppressor genes. We investigat...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90099-u
更新日期:1993-07-30 00:00:00
abstract::Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90080-s
更新日期:1993-06-15 00:00:00
abstract::The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90073-i
更新日期:1993-06-15 00:00:00
abstract::Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90168-9
更新日期:1993-05-14 00:00:00
abstract::Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90163-4
更新日期:1993-04-30 00:00:00
abstract::We used antisense RNA to inhibit the expression of oncogene neu and investigated the effects of diminished neu expression on the phenotypes of B104 cells containing activated oncogene neu. Antisense MT-neu and pSV-neo plasmids were cotransfected into neuroblastoma B104 cells. Southern analysis showed the integration o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90028-8
更新日期:1993-04-15 00:00:00
abstract::Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were fo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90027-7
更新日期:1993-04-15 00:00:00
abstract::Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active di...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90138-y
更新日期:1993-02-01 00:00:00
abstract::Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90144-x
更新日期:1993-02-01 00:00:00
abstract::Inclusion of 10% ethanol with 6.8 ppm N-nitrosodiethylamine in the drinking water of strain A male mice resulted in a 4-fold enhancement of multiplicity of lung tumors and a 16-fold increase in incidence of fore-stomach tumors, compared with carcinogen alone. Given with 40 ppm N-nitrosopyrrolidine, ethanol caused a 5....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90220-4
更新日期:1993-01-15 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90134-h
更新日期:1992-12-24 00:00:00
abstract::Malachite green (MG), an industrial compound and potential environmental health hazard, is highly cytotoxic to mammalian cells in culture. In an attempt to define the biochemical basis, we have compared the cytotoxic effects and morphological alterations shown by MG in Syrian hamster embryo (SHE) cells with the levels...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90131-e
更新日期:1992-12-24 00:00:00
abstract::We examined the responsiveness of normal and neoplastic lung cells to agents which stimulate cAMP production. While their basal cAMP levels were similar, spontaneous in vitro transformant E9 cells and tumor-derived PCC4 cells produced much less cAMP in response to 1 microM isoproterenol compared to non-tumorigenic C10...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90137-k
更新日期:1992-12-24 00:00:00
abstract::Several clinical protocols are attempting to utilize the combined anti-proliferative signal of interferon-alpha (INF-alpha) and tamoxifen on cancer cells. We demonstrated here that the effect of these two agents on the growth of the premacrophage U937 cells is antagonistic. This antagonistic effect is paralleled by th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90003-e
更新日期:1992-10-30 00:00:00
abstract::The anticarcinogenic action of the garlic constituent diallyl sulfide (DAS), was examined in the hamster buccal pouch and forestomach. Groups of hamsters were topically treated, for up to 14 weeks, with a 0.5% solution of the buccal pouch and forestomach carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Prior to, duri...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90249-u
更新日期:1992-10-21 00:00:00
abstract::Data were obtained on soluble oestrogen (ER) and progesterone (PR) receptors from 273 primary breast tumours, using an enzyme immunoassay (EIA) and ligand binding assay with dextran-coated charcoal (DCC) or isoelectric focussing separations. The p29 and total cathepsin D content was also assayed in the same samples. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90246-r
更新日期:1992-10-21 00:00:00
abstract::Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90220-p
更新日期:1992-09-30 00:00:00